Profile: Irvin Dickerson |
| ABC@home member since | 12 Mar 2009 |
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Beta-Lactams were bactericidal against 8 to 10 strains tetracycline at two times the MIC after 24 h, with slower killing at earlier time periods. 25 to 8.0 microg/ml). At 3 and 6 h, killing by ABT-773 was slower, with 99.9% killing of four strains at two times the MIC after 6 h. Amoxicillin was only active against beta-lactamase-negative online pharmacy strains, and cefprozil had the highest MICs of all oral cephalosporins tested (0.5 to gt;32.0 microg/ml). Catarrhalis strains, with beta-lactams killing more rapidly than other drugs. Time-kill studies against 10 H. Similar results were found for azithromycin ( Zithromax ), with slightly slower killing by erythromycin, clarithromycin, and roxithromycin, especially at earlier times. Of the beta-lactams, ceftriaxone had the lowest MICs (lt;/ 0.004 to 0.016 microg/ml), follo by cefixime and cefpodoxime (0.008 to 0.125 and lt;/ 0.125 to 0.25 microg/ml, respectively), amoxicillin-clavulanate (0.125 to 4.0 microg/ml), and cefuroxime (0. Against 50 Moraxella catarrhalis strains, all of the compounds except aldara amoxicillin and cefprozil were active. Against 210 Haemophilus influenzae strains (39.0% beta-lactamase positive), microbroth dilution tests sho that azithromycin ( Zithromax ) and ABT-773 had the lowest MICs (0.5 to 4.0 and 1.0 to 8.0 microg/ml, respectively), follo by clarithromycin and roxithromycin (4.0 to gt;32.0 microg/ml). Influenzae strains sho that ABT-773, at two times the MIC, was bactericidal against 9 of 10 strains, with 99% killing of all strains at the MIC after 24 h; at 12 h, ABT-773 gave 90% killing of all strains at two times the MIC. Beta-Lactam PAEs were similar and shorter than those of the ketolide-macrolide-azalide group for all strains tested.. Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 compared to their susceptibilities to 11 other agents.The activity of the ketolide ABT-773 against Haemophilus and Moraxella was compared to those of 11 other agents. Most compounds gave good killing of five M. ABT-773 and azithromycin ( Zithromax ) gave the longest postantibiotic effects (PAEs) of the ketolide-macrolide-azalide group tested (4.4 to gt;8.0 h), follo by clarithromycin, erythromycin, and roxithromycin. | |
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